中文摘要：

目的：研究原生痛的急性毒性和镇痛抗炎作用。方法：以Bliss法计算原生痛单次ig小鼠的LD州以小鼠扭体法、热板法及大鼠压痛法测定其镇痛作用；以角叉菜胶致大鼠足肿胀模型、小鼠腹腔毛细血管通透性模型及佐剂致大鼠关节炎模型观察原生痛抗炎作用。结果：原生痛LD。为30．10g·kg^-1；95％的可信限为25．85～34．66g·kg^-1。小鼠0．184，0．369g·kg^-1和大鼠0．184g·kg^-1以上剂量，对化学刺激性、热刺激性或机械刺激性疼痛均有明显的镇痛作用。对非特异急性炎症模型或佐剂性关节炎模型也有显著的抗炎作用。结论：原生痛一次性给药镇痛作用突出，且有较宽的安全窗，适用于风湿性关节炎等病症疼痛明显者缓急之用。

英文摘要：

Objective： To study the analgesic and anti-inflammatory actions of Yuanshengtong formula （YSTF）, as well as the acute toxicity of YSTF. Method： The median lethal dose （LDs0） of YSTF to mice was calculated with Bliss method. Writhing method and hot plate method in mice and tenderness test in rats were used to evaluate the analgesic effect. Paw swelling caused by carrageenan in rats, increased permeability of abdominal cavity induced by acetic acid in mice, adjuvant arthritis model in rats was established by Freund＇s complete adjuvant. The anti-inflammatory effect of YSTF was evaluated. Result： The LD5o of YSTF was 30. 10 g ·kg^-1 with the 95% confidenee range of 25.85-34.66 g ·kg^-1. YSTF had prominent analgesic and anti-inflammatory effects both in mice at 0. 184 and 0. 369 g ·kg^-1 and more than O. 184 g·kg^-1 in rats. Conclusion： YSTF has significant analgesic effect and exhibits low toxicity. It can be applied to slow down rheumatic arthritis and other disease with sharp pain.