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中文摘要：
目的研究五加生化胶囊对气虚血瘀模型大鼠血液流变学和细胞内皮因子的影响,探讨其活血化瘀的作用机制。方法采用疲劳、饥饿、寒凉、注射肾上腺素等综合因素复制了大鼠气虚血瘀模型,灌胃给药4周后比较五加生化胶囊不同剂量对该模型大鼠血液流变学指标及内皮素-1（ET-1）、一氧化氮（NO）、6-酮-前列腺素F1a（6-keto-PGF1a）和血栓素B2（TXB2）量的影响。结果造模后大鼠的全血黏度、红细胞聚集指数和血小板聚集指数明显升高。与模型组比较,五加生化胶囊高﹑中剂量组的全血黏度、红细胞聚集指数和血小板聚集指数显著降低（P〈0.05或P〈0.01）。模型组中NO、6-keto-PGF1a量明显低于正常组,ET-1、TXB2量明显高于正常组（P〈0.05或P〈0.01）。与模型组比较,五加生化高﹑中剂量组中NO,6-keto-PGF1a明显升高,ET-1、TXB2明显降低（P〈0.05或P〈0.01）。结论五加生化胶囊可显著改善大鼠血液流变性,具有明显的活血化瘀作用。
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