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Oncolytic adenovirus SG600-IL24 selectively kills hepatocellular carcinoma cell lines
  • ISSN号：1007-9327 (Print)
  • 期刊名称：World J Gastroenterol
  • 时间：0
  • 页码：4677-4684
  • 语言：英文
  • 分类：R735.7[医药卫生—肿瘤;医药卫生—临床医学]
  • 作者机构：[1]Tongji Univ, Shanghai E Hosp, Dept Gen Surg, Shanghai 200120, Peoples R China, [2]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Biliary & Pancreat Surg, Wuhan 430030, Hubei, Peoples R China
  • 相关基金：Supported by National Natural Science Foundation of China,No. 30872510;; Natural Science Foundation of Hubei Province,No. 2008CDB127
  • 相关项目：细胞色素C在MDA-7/IL-24特异性杀伤肝癌细胞靶点地位的研究
作者： 王从俊|
中文摘要：

AIM: To investigate the effect of oncolytic adenovirus SG600-IL24 and replication-incompetent adenovirus Ad.IL-24 on hepatocellular carcinoma (HCC) cell lines and normal liver cell line. METHODS: HCC cell lines (HepG2, Hep3B and MHCC97L) and normal liver cell line (L02) with a different p53 status were infected with SG600-IL24 and Ad.IL-24, respectively. Melanoma differentiation-associated (MDA)-7/interleukin (IL)-24 mRNA and protein expressions in infected cells were detected by reverse transcription-polym...

英文摘要：

AIM: To investigate the effect of oncolytic adenovirus SG600-IL24 and replication-incompetent adenovirus Ad.IL-24 on hepatocellular carcinoma (HCC) cell lines and normal liver cell line. METHODS: HCC cell lines (HepG2, Hep3B and MHCC97L) and normal liver cell line (L02) with a different p53 status were infected with SG600-IL24 and Ad.IL-24, respectively. Melanoma differentiation-associated (MDA)-7/interleukin (IL)-24 mRNA and protein expressions in infected cells were detected by reverse transcription-polym...

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细胞色素C在MDA-7/IL-24特异性杀伤肝癌细胞靶点地位的研究
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