中文摘要：

目的：研究逍遥散对慢性温和不可预知应激（CUMS）模型大鼠的行为学及血浆内单胺类神经递质含量的影响。方法：以逍遥散和两种阳性药（盐酸氟西汀和文拉法辛）为干预药物,应用慢性温和不可预知应激对大鼠进行为期3周的造模,在造模的同时给予实验药物。3周后停止刺激,但继续给药1周。实验过程中,定期测定大鼠体重、糖水偏爱比,以及穿越格数、直立次数和静止时间等。于第29天处死大鼠,采集血样。采用高效液相色谱-荧光检测法,测定各组大鼠血浆中去甲肾上腺素（NA）及5-羟色胺（5-HT）的含量。结果：与空白组比较,模型组大鼠造模3周体重增长缓慢（P〈0.01）,活动次数明显减少（P〈0.01）,糖水偏爱比显著降低（P〈0.05）;而与模型组比较,连续给药4周,逍遥散高剂量组（92.5 g·kg^-1）、中剂量组（46.3 g·kg^-1）以及阳性对照组均能明显增加大鼠体重和行为活动量（P〈0.01）,逆转模型大鼠糖水偏爱百分比的降低（P〈0.05）。连续给药4周,逍遥散高、中、低（23.1 g·kg^-1）剂量组以及文拉法辛组能明显提高模型大鼠血浆NA含量（P〈0.05）。结论：逍遥散对CUMS抑郁模型大鼠表现出抗抑郁作用,且可能与提高模型大鼠血浆中NA含量有关。

英文摘要：

Objective：To study the effect of Xiaoyaosan on changes of behavior and plasma monoamine neurotransmitters on chronic unpredictable mild stress（CUMS） model in rats.Method：The stimulus on CUMS model lasted 3 weeks.At the beginning of stimulus,the rats were treated with the decoction of Xiaoyaosan or two positive drugs（fluoxetine and cultural venlafaxine） for 4 weeks.During the experiment,body weight,the percentage of sucrose preference and data of open-field test（including ambulation numbers,rearing numbers,immobility time） were detected,which was to evaluate the anti-depression action of Xiaoyaosan.In the 4th week,all rats were decapitated after the last treatment,then blood was immediately isolated for detecting the concentration of NA and 5-HT by HPLC-fluorescence detection.Result：After 3 weeks of CUMS procedure,body weight,number of activities and percentage of sucrose preference of the rats in model group decreased significantly compare with control group（P 〈 0.01 and P 〈 0.05,respectively）.Continually administrated for 4 weeks,the body weight,activity times and percentage of sucrose preference in the model group treated with Xiaoyaosan（92.5 g·kg^-1 and 46.3 g·kg^-1） increased significantly（P 〈 0.01 and P 〈 0.05,respectively） compared with model group.Continuous treatment of 92.5,46.3 g·kg^-1 and 23.1 g·kg^-1 Xiaoyaosan for 4 weeks could increase the concentration of NA in plasma（P 〈 0.05）.Conclusions：It suggested that Xiaoyaosan had the antidepression effect and the anti-depression effect was possibly related to increasing the concentration of NA in plasma.