中文摘要：

目的探讨脑卒中急性期患者卒中后抑郁（PSD）的发生率及其危险因素。方法连续入组的发病24h内入院的急性脑卒中患者127例,根据入院14d内汉密尔顿抑郁量表（17项）和蒙哥马利抑郁量表评分分为PSD组和非PSD组,分析PSD与性别、婚姻状况、年龄、文化程度、卒中类型、病灶部位、脑梗死容积、高血压、糖尿病、冠心病、吸烟、饮酒、体质量指数（BMI）、卒中家族史、卒中病史、颈动脉斑块、美国国立卫生研究院卒中量表（NIHSS）评分、Barthel指数（BI）和简易精神状态检查（MMSE）量表评分等临床因素的关系。结果本组PSD发生率为37.0%（47例）。PSD组脑梗死比率、伴高血压病比率、脑梗死容积、入院时NIHSS评分均明显高于非PSD组,BI和MMSE评分均明显低于非PSD组（P〈0.05～0.01）。多因素Logistic回归分析显示脑梗死、高血压和入院时BI与PSD独立相关（OR=5.084,95%CI：1.255～20.592,P=0.023;OR=4.846,95%CI：1.447～16.225,P=0.010;OR=0.966,95%CI：0.951～0.981,P〈0.001）。结论脑卒中急性期患者PSD的发生率较高,脑梗死、高血压和入院时BI是PSD的独立危险因素。

英文摘要：

Objective To investigate the incidence and its risk factors of post-stroke depression（PSD） in cerebral stroke patients at acute stage.Methods 127 stroke patients consecutive admitted to hospital within 24 h onset were divided into PSD group and non-PSD group according to the scores of 17-item Hamilton Depression Rating scale （HAMD） and Montgomery Asberg Depression Rating Scale （MADRS） in the 14 d after admission. The relationship between PSD and clinical factors including sex,marital status,age,education,stroke type,lesion location,infarct volume,hypertension,diabetes,coronary artery disease,smoking,drinking,BMI,family history of stroke,personal history of stroke,score of National Institutes of Health Stroke Scale （NIHSS）,Barthel Index （BI）,and score of mini mental statue examination （MMSE） were analyzed.Results The PSD incidence in this group was 37.0%（47 cases）. In PSD group,the percentage of cerebral infarction and hypertension,the infarct volume and scores of NIHSS on admission were significantly higher,BI and score of MMSE on admission were significantly lower than non-PSD group （P0.05-0.01）. Multifactor regression analysis showed that the PSD was independently associated with cerebral infarction,hypertension,and BI on admission （OR=5.084,95%CI：1.255-20.592,P=0.023;OR=4.846,95%CI：1.447-16.225,P=0.010;OR=0.966,95%CI：0.951-0.981,P0.001;respectively）.Conclusions The incidence of PSD in patients with cerebal stroke at acute stage is high. The cerebral infarction,hypertension and BI on admission are the independent risk factors of PSD.