中文摘要：

目的：优选枳壳中脂溶性部位成分的最佳提取工艺。方法：HPLC测定枳壳中5种脂溶性成分meranzin hydrate、马尔敏、川陈皮素、红橘素和葡萄内酯的含量,以5种脂溶性成分的含量和脂溶性部位浸膏得率为指标,采用L9（34）正交试验法优化枳壳脂溶性部位成分的提取工艺。结果：枳壳优化后的脂溶性部位成分提取工艺为A2B2C2D2,乙醇浓度85%、料液比1∶8、水浴回流1h,提取2次;以5种脂溶性成分的含量计算,则脂溶性部位成分平均含量为2.86（mg/g）,RSD为1.32%,脂溶性部位浸膏的平均得率为2.81%,RSD为1.78%。结论：该提取工艺方法简单、稳定可行,可为枳壳中脂溶性部位成分的大规模化生产工艺提供理论依据。 更多还原

英文摘要：

AIM： To study the optimum extraction of liposoluble constituents from immature bitter orange（Fructus Aurantii）. METHODS： The content of meranzin hydrate,marmin,nobiletin,tangeretin,auraptene in immature bitter orange were determined by RP-HPLC and the extraction yield was adopted as marker,the orthogonal design L9（34） was used to evaluate extraction. RESULTS： The optimal parameters were as follows： immature bitter orange extract was produced with 70% ethanol refluxing,1 h,2 times,herb-to-extract ratio was about 1∶ 8. The mean content of five constituents was 2. 86（mg/g）（ RSD = 1. 32% ） and the extraction yield of liposoluble constitutents was 2. 81% （ RSD = 1. 78% ）. CONCLUSION： This method is simple,stable,reliable and can provide solid basis for large scale extraction of liposoluble constitutents.