中文摘要：

瞄准：调查影响肾并且在生活施主肝移植(LDLT ) 的 transplant 以后 hyperlipidemia (PTHL ) 上的接枝功能。方法：在一个单个中心从 2007 年 1 月经历 LDLT 到 2009 年 5 月的 115 个成年病人的一个总数被注册。数据被中国肝收集并且分析回顾地移植登记。PTHL 被定义为浆液 triglycerides 150 mg/dL 或浆液胆固醇为在在 LDLT 以后的第六个月的 pharmacologic 治疗的 200 mg/dL 或需要。早肾的机能障碍(ERD ) 被定义为浆液 creatinine 为在第一个 transplant 以后星期内的肾的代替治疗的 2 mg/dL 或需要。结果：在 115 个合格病人， PTHL 的发生是 24.3% 。有 PTHL 的接受者显示出 transplant 以后的更高的发生没有 PTHL 的与那些相比的心血管的事件(17.9% 对 4.6% ， P = 0.037 ) 。浆液 creatinine 与全部的浆液 triglycerides 显示出重要积极关联，在 transplant 以后月 1 和 3 点(P < 0.01 ) 。有有的 ERD 的病人更高很预先移植浆液 creatinine 层次(P < 0.001 ) 并且更长的持续时间预先移植肾的不足(P < 0.001 ) 比那些没有 ERD。预先移植浆液 creatinine， graft-to-recipient 重量比率，接枝卷 / 标准肝体积比率，身体团索引(BMI ) 和 ERD 被 univariate 分析为 PTHL 作为风险因素识别。而且， ERD [机会比率(或)= 9.593， P < 0.001 ] 并且 BMI (或 = 6.358， P = 0.002 ) 被 multivariate 分析为 PTHL 作为独立风险因素识别。结论：肾的功能仔细在 LDLT 与 PTHL 的开发被联系。transplant 以后肾的机能障碍，它主要源于预先移植肾的不足，贡献 PTHL。

英文摘要：

AIM：To investigate the impact of renal and graft function on post-transplant hyperlipidemia（PTHL） in living donor liver transplantation（LDLT）.METHODS：A total of 115 adult patients undergoing LDLT from January 2007 to May 2009 at a single center were enrolled.Data were collected and analyzed by the China Liver Transplant Registry retrospectively.PTHL was defined as serum triglycerides ≥ 150 mg/dL or serum cholesterol ≥ 200 mg/dL or the need for pharmacologic treatment at the sixth month after LDLT.Early renal dysfunction（ERD） was defined as serum creatinine ≥ 2 mg/dL and/or the need for renal replacement therapy in the first post-transplant week.RESULTS：In 115 eligible patients,the incidence of PTHL was 24.3%.Recipients with PTHL showed a higher incidence of post-transplant cardiovascular events compared to those without PTHL（17.9% vs 4.6%,P = 0.037）.Serum creatinine showed significant positive correlations with total serum triglycerides,both at posttransplant month 1 and 3（P 0.01）.Patients with ERD had much higher pre-transplant serum creatinine levels（P 0.001） and longer duration of pre-transplant renal insufficiency（P 0.001） than those without ERD.Pretransplant serum creatinine,graft-to-recipient weight ratio,graft volume/standard liver volume ratio,body mass index（BMI） and ERD were identified as risk factors for PTHL by univariate analysis.Furthermore,ERD [odds ratio（OR） = 9.593,P 0.001] and BMI（OR = 6.358,P = 0.002） were identified as independent risk factors for PTHL by multivariate analysis.CONCLUSION：Renal function is closely associated with the development of PTHL in LDLT.Post-transplant renal dysfunction,which mainly results from pre-transplant renal insufficiency,contributes to PTHL.