中文摘要：

Th17 房间是 CD4 的一个新子集 < 啜 class= “ a-plus-plus ” > 涉及细胞外的病原体和真菌的清理的 + T 房间。积累的证据建议 Th17 房间和他们的签名 cytokines 在多重自体免疫调停的致病有一个枢轴的角色煽动性的疾病。这里，我们在自体免疫的疾病的开发和致病在 Th17 功能上总结最近的研究进步。我们也建议鉴别操作 Th17 的新小分子混合物工作让潜在的治疗学的申请治疗人的自体免疫的疾病，包括风湿性关节炎，全身的豺狼座 erythematosus， Sj ? grens 症候群，煽动性的肠疾病，和多重硬化。

英文摘要：

Th17 cells are a new subset of CD4^＋ T cells fungi. Accumulating evidence suggests that Tb17 cells involved in the clearance of extracellular pathogens and and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases. Here, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmune diseases. We also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic application to treat human autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjogren＇s syndrome, inflammatory bowel disease, and multiple sclerosis.