中文摘要：

因为这些 nanomaterials 的长期的保留，许多无机的 nanomaterials 的临床的翻译被毒性问题严重地在身体妨碍。在这研究，我们基于极端小的瞬间 ₂ nanodots 开发了一个 bio-clearable theranostic 代理人，它被一条灵巧的自底向上的途径通过铵 tetrathiomolybdate 的一步舞 solvothermal 分解综合。在由谷胱甘肽(GSH ) 的修正以后，没有聚集，获得的瞬间 ₂-GSH nanodots 在各种各样的生理的缓冲区展出了 sub-10-nm 水动力学直径。没有出现在 vitro 毒性可估计，如此的瞬间 ₂-GSH nanodots 与强壮在红外线附近(NIR ) 吸收度能导致癌症房间的显著 photothermal 脱离。在之上静脉内(i.v ) 注射，瞬间 ₂-GSH nanodots 的有效肿瘤累积被 photoacoustic 成像观察，并且进一步由瞬间的 biodistribution 的分析证实了。尤其是，与有更大的尺寸的常规瞬间 ₂ nanoflakes 相对照，瞬间 ₂-GSH nanodots 经由尿显示出有效身体清理，在注射剂量的多数在就七天以内被清除的地方。老鼠上的肿瘤的 Photothermal 脱离然后与瞬间 ₂-GSH nanodots 被认识到，完成优秀治疗学的功效。这研究与有效肿瘤 homing/treatment 能力，以及快速的身体清理行为介绍极端小的 nanoparticle 的一种新类型，为没有长期的毒性担心的癌症 theranostics 使它有希望。

英文摘要：

The clinical translation of many inorganic nanomaterials is severely hampered by toxicity issues because of the long-term retention of these nanomaterials in the body. In this study, we developed a bio-clearable theranostic agent based on ultra-small MoS2 nanodots, which were synthesized by a facile bottom-up approach through one-step solvothermal decomposition of ammonium tetrathiomolybdate. After modification by glutathione （GSH）, the obtained MoS2-GSH nanodots exhibited sub-10-nm hydrodynamic diameters without aggregation in various physiological buffers. Without showing appreciable in vitro toxicity, such MoS2-GSH nanodots with strong near-infrared （NIR） absorbance could induce remarkable photothermal ablation of cancer cells. Upon intravenous （i.v.） injection, efficient tumor accumulation of MoS2-GSH nanodots was observed by photoacoustic imaging, and further confirmed by analysis of the biodistribution of Mo. Notabl）4 the MoS2-GSH nanodots, in contrast to conventional MoS2 nanoflakes with larger sizes, showed rather efficient body clearance via urine, where the majority of the injected dose was cleared within just seven days. Photothermal ablation of tumors on mice was then realized with the MoS2-GSH nanodots, achieving excellent therapeutic efficacy. This study presents a new type of ultra-small nanoparticle with efficient tumor homing/treatment abilities, as well as rapid body clearance behavior, making it promising for cancer theranostics without long-term toxiciW concerns.