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二维过渡金属硫族化合物在生物医学中的应用
  • ISSN号：0567-7351
  • 期刊名称：《化学学报》
  • 时间：0
  • 分类：TQ174.759[化学工程—陶瓷工业;化学工程—硅酸盐工业] TM914.41[电气工程—电力电子与电力传动]
  • 作者机构：[1]State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China, [2]Institute of Functional Nano & Soft Materials, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China
  • 相关基金：Acknowledgements This work was supported by the National Natural Science Foundation of China （Nos. 51302180, 51222203, 51002100, and 51132006）, the National Basic Research Program of China （Nos. 2011CB911002 and 2012CB932601）, and a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
作者： 刘腾[1], 程亮[1], 刘庄[1]
关键词： 二氧化钛纳米粒子, 光热转换, 癌症治疗, 生物相容性, 生物毒性, 临床应用, 钛氧化物, 纳米材料, photothermal therapy,titanium oxides,biocompatibility,photothermal conversion
中文摘要：

photothermal 治疗(PTT ) 技术为癌症治疗被认为是一个有希望的方法。然而，阻止它的临床的申请的障碍之一是存在的 non-degradability 和 biotoxicity 重金属、基于碳的治疗学的代理人。因此，有高 photothermal 效率，低毒性，和好 biocompatibility 的 PTT 材料着急地被想要。此处，我们报导钛有为 PTT 过程的高功效和低毒性的基于氧化物的治疗学的代理人。我们表明了那 Magn

英文摘要：

The photothermal therapy （PTT） technique is regarded as a promising method for cancer treatment. However, one of the obstacles preventing its clinical application is the non-degradability and biotoxicity of the existing heavy-metal and carbon-based therapeutic agents. Therefore, a PTT material with a high photothermal efficiency, low toxicity, and good biocompatibility is urgently wanted. Herein, we report a titanium oxide-based therapeutic agent with a high efficacy and low toxicity for the PTT process. We demonstrated that Magneliphase Ti8015 nanoparticles fabricated by the arc-melting method exhibit 〉98% absorption of near infrared light and a superior photothermal therapy effect in the in vivo mouse model. The Ti8O15 nanoparticle PTT material also shows a good biocompatibility and biosafety. Our study reveals Magneli-phase titanium oxide as a new family of PTT agents and introduces new applications of titanium oxides for photothermal conversion.

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期刊信息
  • 《化学学报》
  • 北大核心期刊（2014版）
  • 主管单位:中国科学院
  • 主办单位:中国化学会 中国科学院上海有机化学研究所
  • 主编：周其林
  • 地址：上海市零陵路345号
  • 邮编：200032
  • 邮箱：hxxb@sioc.ac.cn
  • 电话：021-54925085
  • 国际标准刊号：ISSN：0567-7351
  • 国内统一刊号：ISSN：31-1320/O6
  • 邮发代号:4-209
  • 获奖情况:
  • 首届国家期刊奖,第二届国家期刊奖提名奖,中国期刊方阵“双高期刊”
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,英国英国皇家化学学会文摘,中国北大核心期刊（2000版）
  • 被引量:28694