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中文摘要：
瞬时受体电位香草酸亚型1（transient receptor potential vanilloid subfamily,member 1,TRPV1）是瞬时电压感受器阳离子通道（transient receptor potential cation channel,TRP）家族成员之一,可被伤害性热刺激或一些化学分子所激活,在热痛觉敏化形成过程中发挥重要作用,其功能活性在转录后水平受到多种方式的调控。近年来,磷脂酰肌醇4,5二磷酸（phosphatidylinositol 4,5-bisphosphate,PIP2）调节离子通道活性的研究不断深入,因此PIP2对TRPV1的调控作用受到愈来愈多的关注,但研究结果尚存一些争议。本文着重就近年来,对于PIP2对TRPV1的活性调控以及二者之间的结合等方面的研究进展加以整理和总结。
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