中文摘要：

二 triblock 聚合物， tetraaniline-block-poly (N-isopropyl acrylamide )-block-poly(hydroxyethyl acrylate )(TA-b-PNIPAM-b-PHEA ) 并且 TA-b-PHEA-b-PNIPAM，被二个步方法与不含糊的结构综合。这二 diblock 聚合物的差别是 carboxyl 组的连接顺序堵住，例如， carboxyl 组到为 PNIPAM-b-PHEA 的 PNIPAM 块并且到为 PHEA-b-PNIPAM 的 PHEA 块。第二，块 tetraaniline 通过 amidation 被连接到 diblock 聚合物产出相应 triblock 共聚物。他们俩几乎有相同化学作文。唯一的差别是在 triblock 聚合物的每块的连接顺序。当他们在在一个合适的答案的 45 °C 是自我装配的时，两个与大约 400 nm 的平均直径在他们的表面上与细微缺点他们的总数有球形的形状。当他们的总数分散被凉下来到 20 °C 时，仅仅 TA-b-PHEA-b-PNIPAM 的形态学不管多么变化了，形成有从球形的总数转变的大约 100-200 nm 的直径的像蠕虫的总数。在这 triblock 共聚物的每块的 amphiphilic 性质和位置为这形态学转变是很必要的。因为我们的组这里介绍的像蠕虫的总数有空结构里面，它为 doxorubicin 的控制版本性质被评估。药版本实验显示与温度变化一起，中间的层结构的重新整理在总数引起了形态学变化，因此加速药版本的速度。

英文摘要：

Two triblock polymers, tetraaniline-block-poly（N-isopropyl acrylamide）-block-poly（hydroxyethyl acrylate） （TA-b-PNIPAM-b-PHEA） and TA-b-PHEA-b-PNIPAM, were synthesized with unambiguous structure by a two step method. The difference of these two diblock polymers is the connection order of carboxyl group to block, e.g., carboxyl group to PNIPAM block for PNIPAM-b-PHEA and to PHEA block for PHEA-b-PNIPAM. Secondly, block tetraaniline was linked to the diblock polymer through amidation to yield the corresponding triblock copolymer. Both of them have almost the identical chemical compositions. The only difference is the connection order of each block in the triblock polymers. When they were self-assembled at 45℃ in a suitable solution, both of their aggregates have spherical shape with slight defects on their surface with the average diameter of about 400 nm. However, when their aggregate dispersion was cooled down to 20 ℃, only TA-b-PHEA-b-PNIPAM＇s morphology changed, forming worm-like aggregates with the diameter of about 100-200 nm transformed from spherical ag- gregates. Both amphiphilic property and position of each block in this triblock copolymer are very essential for this morphology transformation. Since the worm-like aggregates presented here by our group have hollow structure in- side, its controlled release properties for doxorubicin were evaluated. Drug release experiment indicated that along with the temperature changes, the rearrangement of the intermediate layer structure caused morphology change in aggregate, thus accelerating the speed of drug release.