中文摘要：

8-氮杂腺嘌呤是抗代谢类药物，临床上广泛用于治疗增殖很快的肿瘤。文章以溴化乙啶为探针，通过紫外光谱，荧光光谱，研究了8-氮杂腺嘌呤及其与Co^2＋和Cu^2＋离子形成的配合物同DNA的作用。结果发现：在pH9．86时，8-氮杂腺嘌呤可与Co^2＋形成稳定配合物，此配合物与DNA之间静电作用较强、嵌插作用较弱；在pH7．4时，8-氮杂腺嘌呤可与Cu^2＋形成稳定配合物，其与DNA之间主要以嵌插作用为主、静电作用为辅；在pH2．85时，8-氮杂腺嘌呤-Cu^2＋配合物与DNA之间嵌插作用较强、静电作用较弱；在pH7．4时，8-氮杂腺嘌呤几乎不影响EB和DNA之间的嵌入结合方式，它与DNA为静电方式结合。这些结果，可为合理改善药效，降低抗癌药物毒性和设计新药提供理论依据。

英文摘要：

The mechanism of the interactions of 8-azaadenine and its Co^2＋ and Cu^2＋ complexes with DNA was studied by UV and fluorescence spectra using ethidium bromide（EB） as the probe molecule. When pH 9.86, the action of 8-azaadenine-Co^2＋ with DNA was electrostatic effect and certain kind of intercalation action, when pH 7.4, the action of 8-azaadenine-Cu^2＋ with DNA was intercalation action and certain kind of electrostatic effect, when pH 2. 85, the action was intercalation action and certain kind of electrostatic effect. But when pH 7.4, 8-azaadenine hardly influenced the intercalation action of EB and DNA, and the action of 8-azaadenine and DNA was electrostatic action.