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中文摘要：
DNA折纸术（DNA origami）作为一种精确高效的自组装技术，自2006年Rothemund发明以来在生物医药、高灵敏度检测、纳米光电子器件、等离子体光子学等领域展现出巨大的应用潜力，近年来受到广大研究者的高度关注。利用DNA折纸术构建纳米材料是以DNA origami结构为载体，通过碱基互补配对的原则及三维结构上可程序化设计和可寻址的特点精确地组装很多功能基团如金属及半导体纳米颗粒，蛋白质和单壁碳纳米管等，并应用于研究无标记的RNA杂交检测、单分子的化学反应、检测间距对多价态的配位体．蛋白质之间键合的影响等。本文对近几年来DNA origami构建功能纳米材料的研究进展加以系统综述，并对DNA origami的发展方向和应用前景进行了展望。
英文摘要：
DNA origami, an efficient self-assembly technique, has shown great potential for applications in biomedicine, biosensing, nanooptoelectronic device and nanophotonics. It has received strong attention from researchers in a wide range of fields. The programmability and three dimensional addressability of DNA origami architectures have been utilized to precisely organize various functional groups, such as metallic nanoparticles, semiconducting nanoparticles, protein molecules and single-wall carbon nanotubes. Meanwhile, DNA origami structures have also been employed to investigate single molecule reactions on them, such as label-free RNA hybridization, formation and break of a chemical bond and distance-dependent multivalent ligand-protein binding. In the present paper, the research progress of organizing functional nanomaterials with DNA origami are reviewed, and the challenges and application prospects are discussed.
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