中文摘要：

目的探讨电针对阿尔茨海默病（AD）的治疗作用和突触超微结构的影响。方法以SAMP8小鼠作为AD动物模型,电针＂百会＂、＂涌泉＂穴,每日1次,7次为1疗程,共3个疗程后,以Morris水迷宫测试小鼠学习记忆能力的变化,评价电针对AD的治疗效应;用电镜观察海马神经元突触界面曲率、突触后致密物厚度（PSD）和突触间隙宽度的变化。结果定位航行实验中,与模型组相比,模针组平均逃避潜伏期缩短（P〈0.05）;空间探索实验中,模针组〔（38.55±3.59）s〕在原平台所在象限停留的时间较模型组〔（30.59±6.02）s〕延长（P〈0.05）;模针组突触后致密物〔（76.928±25.236）nm〕较模型组〔（65.371±24.219）nm〕增厚（P〈0.05）;突触间隙宽度〔（25.941±6.217）nm〕较模型组〔（29.161±7.830）nm〕减小（P〈0.05）;突触界面曲率（1.083±0.049）较模型组（1.062±0.048）变化不明显,呈增大趋向（P〉0.05）。结论电针能改善SAMP8小鼠学习记忆能力,促进海马神经元突触形态可塑性发挥,增强学习记忆信息的传递。

英文摘要：

Objective To investigate the influence of electro-acupuncture（EA）therapy for Alzheimer＇s disease（AD）on the synaptic ultrastructures.MethodsSAMP8 rats were treated with EA therapy on ＇Baihui（Du20）＇ and ＇Yongquan（Kidney1）＇.The treatment was applied once daily and totally for 21 days.The changes of learning and memory abilities of SAMP8 rats were observed and recorded by Morris water maze to evaluate the curative effect of EA therapy.The changes of the general morphous of hippocampal synapse,the curvature of synaptic interface,the thickness of post synaptic density（PSD）and the width of synaptic cleft were observed by electron microscope.ResultsCompared with control group,the average escape latency of EA group was decreased（P〈0.05）;the time of swimming in primary platform quadrant of EA group 〔（38.55±3.59）s〕 were increased than that of control group〔（30.59±6.02）s〕（P〈0.05）.Compared with control group,the structure of neural synapse in EA group was comparatively clear and complete,the thickness of PSD in EA group was increased（P〈0.05）,the width of synaptic cleft in EA group was decreased（P〈0.05）and the curvature of synaptic interface in EA group had no obvious changes and only showed increasing-tendency（P〉0.05）.ConclusionsEA therapy could improve the learning and memory abilities of SAMP8 rats,influence the morphological plasticity in hippocampal synapse,strengthen information transmission of learning and memory.