中文摘要：

目的研究电针对阿尔茨海默病（AD）模型小鼠海马神经细胞黏附分子（NCAM）和核转录因子κB（NF-κB）的影响，从神经细胞黏附角度探讨电针治疗AD的作用机制。方法快速老化模型小鼠（SAMP8）24只采用随机数字表法分为模型组、模型＋针刺组（简称模针组），每组12只；抗快速老化模型小鼠（SAMR1）12只为空白组，每日一次电针模针组小鼠“百会”、“涌泉”穴，连续治疗21d。应用免疫组织化学染色、原位杂交方法检测各组小鼠海马组织NCAM、NF-κB蛋白及mRNA的表达。结果与模型组比较，模针组小鼠NCAM（0．231±0.007）、NF-κB蛋白（0．367±0．012）及mRNA（0．528±0．016，0．308±0．001）阳性表达明显增强，差异有统计学意义（P〈0．05）。结论电针可通过提高NF-κB的表达，诱导NCAM的合成，促进神经细胞黏附。

英文摘要：

Objective To investigate the effect of electro-acupuncture （EA） therapy on the synaptic plasticity of hippocampal neurons in senescence-accelerated mouse （SAMP8） by examining the changes in neural cell adhesion molecule （NCAM） and nuclear factor-κB （NF-κB） expression, and explore the mechanism behind the therapeutic effect of EA on Alzheimer＇s disease （AD） in view of neural cell adhesion. Methods Twenty-four SAMP8 mice as the animal model of AD were randomized equally into the model group and EA treatment group, with 12 lerated resistant mice （SAMR1） mice as the blank control group. EA on Baihui （Du20） and Yongquan （Kid1） was administered once daily for 21 consecutive days in mice in the EA group. The expressions of NCAM and NF-κB mRNA and proteins in the hippocampal neurons were detected by immunohistochemistry and in situ hybridization. Results Compared with the model group, the mice in EA group showed significantly increased expression of NCAM and NF-κB mRNA and proteins （P〈0.05）. Conclusion EA can increase the expression of NCAM and NF-κB in mouse hippocampal neurons. EA can promote the cell adhesion and synapse plasticity of the neurons possibly by upregulating NF-κB expression to induce increased NCAM production.