中文摘要：

目的：评价麦杏补肺汤治疗慢性阻塞性肺疾病（COPD）稳定期肺气亏虚证患者的临床疗效。方法：将广西玉林市中医院呼吸病科2012年6月-2013年6月收治的80例COPD稳定期患者随机分为治疗组和对照组,各40例,对照组参照COPD临床指南稳定期用药进行治疗,治疗组在对照组基础上给予固定组方麦杏补肺汤,治疗3个月。分别在治疗前后对临床症状、成人COPD-QOL生活质量量表、血清IL-8、TNF-α、T细胞亚群等进行评价。结果：治疗后,治疗组对咳嗽、咳痰、喘息、胸闷、乏力的临床疗效显著优于对照组（P〈0.05,P〈0.01）;对生活质量、日常生活能力、社会活动、抑郁心理、焦虑心理、总积分的改善两组间差异均有统计学意义（P〈0.05）;血清IL-8、TNF-α水平组间差异均有统计学意义（P〈0.01）;血清CD＋4T、CD＋8T、CD＋4/CD＋8水平组间差异均有统计学意义（P〈0.05,P〈0.01）。结论：麦杏补肺汤治疗COPD稳定期患者具有较好的临床疗效,能够改善临床症状和呼吸困难,提高生活质量,可能具有延缓肺功能下降的潜在优势。其作用机制可能与降低全身炎性反应,提高免疫功能有关。

英文摘要：

Objective：To evaluate the clinical curative effect of treating chronic obstructive pulmonary disease（COPD）patients with syndrome of syndrome of deficiency of lung qi during stable period with Xingmai Bufei Decoction.Methods：Eighty COPD patients during stable period in pneumology department of Yulin Traditional Chinese Medical Hospital from June 2012 to June 2013 were selected and randomly divided into control group and experimental group,and with 40 patients in each group.Patients in control group were treated refer to the COPD clinical guideline,and patients in experimental group were treated with Maixing Bufei Decoction based on the treatment of control group for 3 months.The clinical symptoms,adult COPD-QOL life quality scale,levels of IL-8,TNF-α and T cell subgroups were evaluated before and after treatment.Results：After treatment,the clinical efficacy on cough,expectoration,gasp,chest distress,and lacking in strength of patients in experimental group was superior to treatment group（P〈0.05,P〈0.01）.The difference in the improvement in activity of daily living,social activity,mental depression,mental anxiety and aggregate score between the two groups was significant（P〈0.05）.The difference in IL-8,TNF-α,CD4＋T,CD8＋T and CD4＋/CD8＋ in serum between the two groups was significant（P〈0.05,P〈0.01）.Conclusion：The clinical efficacy of treating COPD patients during stable period with Maixing Bufei Decoction is good.It not only could improve the clinical efficacy,dyspnea and quality of life,but also could delay the lung function descending of COPD patients during the stable period,and the mechanism might be related with the reducing of systemic inflammatory response and improving of immunologic function.