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石墨烯及其衍生物类药物载体的研究进展
  • 分类:O613.71[理学—无机化学;理学—化学]
  • 作者机构:天津农学院基础科学学院,天津300384
  • 相关基金:国家自然科学基金青年项目“具有开关功能胰岛素载体的制备及其葡萄糖响应性的研究”(21404082);天津市大学生创新创业训练计划项目“pH值响应嵌段共聚物/石墨烯复合药物载体的制备及其性能研究”(201510061095);国家大学生创新创业训练计划项目“温度响应性氧化石墨烯纳米药物控释体的制备及释药性研究”(201610061078)
中文摘要:

石墨烯作为碳材料的新成员,从2004年被发现至今,已引起了科学家的极大兴趣。石墨烯是处于蜂窝状晶体点阵上的碳原子以sp2杂化链接形成的单原子层二维晶体,具有许多独特的理化性质,已成为当前研究的热点之一。石墨烯及其衍生物在载药方面的应用正处在探索阶段,当前,根据实际需求对石墨烯及其衍生物进行药物载体方面的研究是一项极富挑战性的工作。本文重点介绍了石墨烯尤其是氧化石墨烯应用于药物载体方面的最新研究进展,指出了目前石墨烯类材料在药物载体应用中存在的问题,并对其发展进行了展望。

英文摘要:

As the new member of the carbon materials, graphene has brought up great interest of scientists since it was found at 2004. Graphene is a kind of two-dimensional crystal of a single atomic layer which has a honeycomb crystal lattice of carbon atoms in a sp2 hybrid link formation, exhibits many unique physical and chemical properties and excellent performance due to the unique structure. The current studies on graphene and its derivatives mainly concentrated on the field of the physics, chemistry and materials science. The application of graphene and its derivatives on medical materials and drug delivery is still in exploring stage and regarded as a challenging work. In this paper, the latest research progress in the application of graphene and its derivatives in drug carrier are mainly introduced. The existing problems in the application of graphene materials in drug carriers are also pointed out and the possible development is prospected.

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