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Cross-reactivity of anti-H pylori antibodies with membrane antigens of human erythrocytes
  • ISSN号:1007-9327
  • 期刊名称:《世界胃肠病学杂志:英文版》
  • 分类:R818.052.1[医药卫生—放射医学;医药卫生—临床医学]
  • 作者机构:[1]National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, PO Box 5, Changping, Beijing 102206, China
  • 相关基金:Supported by the National Natural Science Foundation of China, No. 30370078
中文摘要:

瞄准:调查 anti-H pylori 抗体是否有与红血球的抗原跨反应膜。方法:血样品从 14 个志愿者被收集(8 积极并且为 13C 脲呼吸检测的 H pylori 的 6 negative 测试) 一般人口。这些题目的红血球膜蛋白质被西方的污点用 anti-H pylori 浆液检验。与积极乐队有关的蛋白质被集体光谱分析识别。结果:与在 H pylori 感染的所有样品独立人士的红血球膜的大约 50 kDa 的蛋白质跨反应的有的 Anti-H pylori 抗体。在积极乐队的一蛋白质作为链 S 被识别,人的红血球 Band-3 的细胞质的领域的晶体结构蛋白质。结论:有人的红血球膜的一些抗原的 Anti-H pylori 抗体跨 react,它可以为在 H pylori 感染和脉管的混乱之间的关系提供线索。

英文摘要:

AIM: To investigate whether anti-H pylori antibodies have cross-reaction with antigens of erythrocyte membrane. METHODS: Blood samples were collected from 14 volunteers (8 positive and 6 negative for Hpylori detected by ^13C-urea breath test) of the general population. Erythrocyte membrane proteins of the subjects were examined by Western blot using anti-H pylori serum. The proteins related to the positive bands were identified by mass spectrum analysis. RESULTS: Anti-Hpylori antibodies had cross-reaction with the proteins of about 50 kDa of erythrocyte membranes in all samples independent of H pylori infection. One protein in the positive band was identified as Chain S, the crystal structure of the cytoplasmic domain of human erythrocyte Band-3 protein. CONCLUSION: Anti-HpyloH antibodies cross-react with some antigens of human erythrocyte membrane, which may provide a clue for the relationship between Hpylori infection and vascular disorders.

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  • 《世界胃肠病学杂志:英文版》
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  • 主办单位:百世登出版集团有限公司
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  • 电话:0351-4078656
  • 国际标准刊号:ISSN:1007-9327
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