中文摘要：

HAS（protein inhibitor of activated STAT）蛋白家族能够与许多蛋白质发生相互作用，其中大部分为转录因子。通过相互作用，HAS蛋白通过影响了蛋白的活性和功能，参与基因的转录调控和包括STAT（Signal transducer and activator of transcription）．Wnt，TGFβ，NF—κB等通路在内的细胞信号通路，具有重要的生理功能。PIAS蛋白的调控机制主要有两种：一种是通过其自身所具有的SUMO（small ubiquitin-related modifiers）E3连接酶活性，促进对一些转录因子、转录辅因子的化学修饰．尤其是SUMO化修饰，从而调控它们的转录活性；另一种是作为构架蛋白，为蛋白质之间的相互作用提供平台，促进细胞信号通路复合物或基因转录复合物中其它调节蛋白的去除和募集，并涉及到靶蛋白的亚核定位。同时，针对不同的靶蛋白，HAS蛋白的上述两种作用机制并不是完全互相排斥的，这体现了HAS蛋白功能的特异性和复杂性。本篇综述将就上述内容作一介绍。

英文摘要：

Protein inhibitor of activated STAT （PIAS） family could interact with many proteins, most of which are transcriptional factors. By interacting with these proteins, PIAS proteins could affect their activation and function, and take part in gene transcriptional regulation and cellular signal pathway including Signal transducer and activator of transcription （STAT）, Wnt, TGFβ, NF-κB pathways and so on, therefore present important biological functions. PIAS proteins play roles mainly through two mechanisms： acting as SUMO E3 ligases to promote modifications of some transcriptional factors and cofactors, especially sumoylation, and to regulate their transcriptional activation; acting as structural proteins to offer platforms for protein-protein interactions and to promote the abstraction and recruitment of other regulators in the cellular signal pathway complexes or gene transcriptional complexes, companied by the subnuclear location of target proteins. Simultaneously, according to different target proteins, these two mechanisms of PIAS proteins are not absolutely repulsive, which indicates the specificity and complexity of the function of PIAS proteins. This paper will give a review about these contents mentioned above.