中文摘要：

许多调控基因转录的重要蛋白质能被SUMO（small ubiquitin-related modifier）化修饰,这些蛋白质包括转录因子,转录辅助因子和染色质修饰酶.SUMO化修饰对底物蛋白的活性产生影响,在大多数情况下,与转录活性的抑制有关.最近,对SUMO化调控转录的机制有了新的认识,认为SUMO化的一个重要作用是促进转录因子与转录抑制因子之间的相互作用.另一方面,已经发现转录共抑制因子HDAC（组蛋白去乙酰化酶）可以作为SUMO化的底物、效应因子和调控因子,说明乙酰化和SUMO化之间复杂的相互作用对基因转录调控起着非常重要的作用.

英文摘要：

Many important transcriptional regulatory proteins can be modified by SUMO （small ubiquitinrelated modifier）, including transcription factors, transcription cofactors and chromatin-modifying enzymes. SUMOylation can modify protein activity and in most cases promote transcriptional repression. Recent reports show that SUMOylation promotes the interactions between transcriptional activators and inhibitors. In addition, it has been found that transcriptional co-repressors HDAC （ histone deacetylase ） can be functioned as substrates, effectors, and regulators of SUMOylation, showing that the complex relationship between acetylation and SUMOylation is important for gene regulation.