目的:确定血塞通注射液中微量元素与其导致红细胞异常溶血的关联性。方法:采用电感偶合等离子体质谱法(ICP-MS)对不同生产厂家及批次的血塞通注射液中25种金属微量元素进行含量测定,并比较异常溶血组与正常溶血组血塞通注射液各微量元素差异。结果:异常溶血组与正常溶血组血塞通注射液重金属元素未见差异,异常溶血组血塞通注射液中锌元素含量相对较高。结论:血塞通注射液异常溶血现象与重金属致异常溶血无关。
Objective: To determine the relevance of microelements in Xuesaitong Injection and erythrocyte abnormal hemolysis induced by the injections. Method: 25 kinds of metal microelements of different batches injections were assayed by ICP-MS method, and the difference between normal hemolysis group and abnormal hemolysis group was compared. Results : No difference existed between normal hemolysis group and abnormal hemolysis group, and the content of Zn of normal hemolysis group was higher than that of the normal hemolysis group. Conclusion: The abnormal hemolysis induced by Xuesaitong Injection was irrelevant to heavy metals.