中文摘要：

目的分析1990与2013年中国人群结直肠癌的疾病负担变化情况。方法利用2013年中国分省疾病负担研究结果，分析1990-2013年问中国人群结直肠癌的发病和死亡变化趋势，及1990年和2013年结直肠癌导致的过早死亡损失寿命年（YLL）、伤残损失健康寿命年（YLD）及伤残调整寿命年（DALY），比较1990年与2013年中国结直肠癌标化死亡率、DALY和DALY率的变化情况。结果中国人群结直肠癌标化发病率从1990年12．15／10万升至2013年20．27／10万，上升66．83％（男性上升72．82％，女性上升55．26％）。结直肠癌标化死亡率从1990年10．57／10万升至2013年11．07／10万，上升4．73％（男性上升9．03％，女性减少3．12％），因结直肠癌死亡人数从1990年7．79万例升至2013年14．80万例，上升90．08％（男性上升105．36％，女性上升72．14％）。2013年中国因结直肠癌造成的DALY为333．16万人年、YLL为320．07万人年、YLD为13．09万人年，YLL是DALY的主要构成部分。1990年中国因结直肠癌造成的DALY为201．91万人年，标化DALY率为238．54／10万，2013年标化DALY率为224．23／10万，DALY上升65．叭％，标化DALY率降低6．00％。各年龄组中，男性结直肠癌死亡率、DALY和DALY率均明显高于女性。结论2013年中国结直肠癌造成的疾病负担仍维持在较高水平；2013年结直肠癌疾病负担总值高于1990年，标化DALY率和标化YLL率降低。

英文摘要：

Objective To analyze the disease burden of colorectal cancer in the Chinese people in 1990 and 2013. Methods Data from the estimation of 2013 Chinese Sub-national Burden of Disease Study was used, to analyze the incidence and mortality of colorectal cancer in China, in 1990 and 2013, among all the Chinese people. Data on the years of lifte lost due to premature mortality （YLL）, years lived with disability （YLD） and disability-adjusted life years （DALY） of colorectal cancer in China, in 1990 and 2013 was also used. Related death rates, DALY and DALY rates were compared. Results The standardized incidence rate of colorectal cancer among Chinese people increased by 66.83% from 12.15/100 000 in 1990 to 20.27/100 000 in 2013 （72.82% for men and 55.26% for women）. The standardized mortality rate of colorectal cancer increased by 4.73% from 10.57/100 000 in 1990 to 11.07/100 000 in 2013 （with 9.03% increase for men but 3.12% decrease for women）. A total number of 148 000 people died from colorectal cancer in 2013, with an increase of 90.08% （105.36% for men and 72.14% for women） compared with the number of 77 900, in 1990. Related data on DALY, YLL and YLD due to colorectal cancer appeared as 3 331.6 thousand person years, 3 200.7 thousand person years and 130.9 thousand person years, respectively in 2013, with YLL as the vast majority of DALY. Compared with 2 019.1 thousand person years in 1990, DALY showed an increase of 65.01% in 2013. However, the standardized DALY rate reduced by 6.00% from 238.54/100 000 in 1990 to 224.23/100 000 in 2013. Parameters as the mortality rates, DALY and DALY rates appeared all higher in men than in women, in every age group. Conclusions The disease burden of colorectal cancer in China remained at high levels in 2013. Compared with the data in 1990, the total disease burden on colorectal cancer showed an increase while the DALY rate and YLL rate showed a decline in 2013.