中文摘要：

慢性肾脏病是影响人民健康的重大疾病之一。六味地黄丸是目前临床运用治疗慢性肾脏病的有效方剂，有一定的临床研究基础，六味地黄丸减轻肾间质纤维化也有广泛的实验研究，作者前期对六味地黄丸和慢性肾衰竭致肾间质纤维化做了大量的研究，但以往的研究大多局限于肾间质纤维化机制过程中的后三个阶段中细胞外基质和细胞因子的研究，很少涉及第一阶段细胞活化层次的研究，从肾小管上皮细胞转分化角度，对六味地黄丸治疗5／6肾切除大鼠慢性肾表、减缓肾间质纤维化机理的深层次研究较少，该文综述六味地黄丸对慢性肾脏病临床和实验研究的新进展。

英文摘要：

Chronic kidney disease is one of the major diseases affecting the health of the people. Liu Wei Di Huang Wan is currently the clinical use of the treatment of chronic kidney disease valid prescription, the basis of certain clinical studies, Liu Wei Di Huang Wan mitigate the renal interstitial fibrosis also have a wide range of experimental research of the pre Liu Wei Di Huang Wan and chronic renal failure caused by renal interstitial fibrosis has done a lot of research, but previous studies mostly confined to the extracellular matrix and cytokines in the last three stages in the process of renal interstitial fibrosis mechanisms rarely involved in the first phase of cell activation levels transdifferentiation angle from renal tubular epithelial cells, treatment of Liu Wei Di Huang Wan 5/6 nephrectomy rats with chronic renal failure, less slow renal interstitial fibrosis mechanism of deep-seated, the paper reviews Liu Wei Di Huang Wan chronic kidney the new progress of the disease clinical and experimental studies.