中文摘要：

目的量化评估屈光参差性弱视患者微扫视性眼球运动的特征，探讨高速眼球运动记录在弱视诊断及客观、定量评估中的应用价值。方法2010年9月至2011年3月，在天津市眼科医院就诊的屈光参差性弱视患者19例（弱视眼19只眼为AM组，对侧眼19只眼为AS组），同期屈光矫正视力正常的同年龄段受试者19例（主导眼19只眼为ND组，非主导眼19只眼为NN组）。采用高速眼球运动记录系统对受试者的双眼分别进行注视性眼球运动记录，采用Matlab程序对微扫视性眼球运动成分进行识别、提取和分析。Origin 8．0统计软件及Matlab 2008统计学工具包对各组微扫视幅度、峰值速度、发生频率、微扫视间隔时间、累积概率分布等量化指标进行分析，多组间比较采用单因素方差分析及Turkey检验。结果AM组0．76°±0．07°微扫视幅度显著高于AS组、ND组和NN组（F=49．95，P=0．000），AM组（79．72±5．64）°／s峰值速度也较AS组、ND组和NN组显著增加（F=4．93，P=0．004），AM组（1．52±0．08）Hz微扫视发生频率较AS组、ND组和NN组明显降低（F=120．39，P=0．000），AM组（537．40±65．47）ms微扫视间隔时间较AS组、ND组和NN组明显延长（F=4．41，P=0．007），AM组幅度依赖的累积概率分布曲线较其余各组右移，AM组0．67°±0．06°累积概率半高幅度较其余各组明显增加（F=203．05，P=0．000）。结论微扫视幅度、峰值速度、发生频率、间隔时间、累计概率分布等可作为客观评价弱视眼眼球运动功能的指标。高速眼球运动记录对客观评估弱视眼球运动系统功能状态具有重要临床价值。

英文摘要：

Objective To quantitatively investigate the characteristics of the microsaccadic eye- movements in anisometropic amblyopia and to evaluate the using value of high-speed eye-movement recording in objective and quantitative evaluation and diagnosis of amblyopia. Methods From September in 2010 to March in 2011, 19 cases of anisometropic amblyopic patients （ 19 amblyopic eyes as group AM and 19 their sound eyes as group AS） and 19 cases of subjects with normal corrected visual acuities （ 19 dominant eyes as group ND and 19 non-dominant eyes as group NN） were recruited from the outpatient clinic at Tianjin Eye Hospital. A high-speed eye-movement recording system was used to monoeularly record the fixational eye-movements of subjects＇ both eyes. A Matlab routine was used to detect and analyze the mierosaecadic components of eye-movement waveforms. The microsaccadic amplitudes, peak velocities, occurrence rates, inter-microsaccadic intervals, cumulative probabilities of all groups were analyzed and compared using Origin8. 0 and Matlab2008 statistics toolbox. Results The mean microsaccadic amplitude of group AM （0. 76 ± 0. 07 ） o was larger than groups AS, ND and NN （ F = 49. 95, P = 0. 000）. The mean peak velocity of group AM （79.72±5.64） °/s was faster than groups AS, ND and NN （ F = 4. 93, P = 0. 004）. The mean occurrence rate of group AM （ 1.52±0. 08） Hz was less than groups AS, ND and NN （ F = 120. 39, P = 0. 000）. The mean inter-microsaccadic interval of group AM （537.40±65.47 ） ms was longer than groups AS, ND and NN （F =4. 41, P =0. 007）. The amplitude dependent cumulative probability curve of group AM shifted to right compared with other groups and its amplitude 0. 67° ± 0. 06° at half cumulative probability was obviously increased compared with other groups （ F = 203.05, P = 0. 000）. Conclusion Microsaccadic amplitude, peak velocity, occurrence rate, inter-microsaccadic interval and cumulative probability could be used as the parameters for objective and qua