中文摘要：

创伤后应激障碍（posttraumatic stress disorder,PTSD）是当机体遭受威胁生命或者强烈精神创伤后发生的疾病。近年来研究发现,5-羟色胺（5-HT）可能通过5-羟色胺转运体 （SERT）、5-HT受体（主要包括5-HT 1A 、5-HT1B、5-HT2A和5- HT2C受体）,以及多巴胺、去甲肾上腺素等神经递质相互作用,参与PTSD的发生,该文就此进行综述。

英文摘要：

Posttraumatic stress disorder（PTSD） is a psychiatric condition that can occur in anyone who has experienced a life-threatening or traumatic event.Clinical and preclinical studies have implied that through stimulation of serotonin transporters,or serotonin receptors（especial 5-HT 1A,5-HT 1B,5-HT 2A or 5-HT2C receptors） or interactions with noradrenergic and dopaminergic system,brain 5-HT plays an important role in the neurobiology of PTSD.This article reviews current understanding of the relationship between 5-HT and PTSD.