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中文摘要：
目的研究小补心汤总黄酮（XBXT-2）对海马及前额皮质神经胶质细胞的影响。方法采用连续28 d每天给予大鼠1或2种不可预测的刺激建立慢性应激模型,同时每日单次ig给予XBXT-2 25和50 mg.kg-1。采用免疫组化方法观察大鼠海马齿状回颗粒下层、CA3区和前额皮质星形胶质细胞的影响。结果免疫组化结果表明,慢性应激大鼠海马齿状回颗粒下层、CA3区和前额皮质星形胶质细胞数目减少,形态萎缩,吸光度值显著降低（P〈0.01）。伴随给予XBXT-2 25和50 mg.kg-1可显著逆转这一改变,吸光度值显著增加（P〈0.01）,阳性药丙米嗪具有同样的作用。结论 XBXT-2可逆转海马齿状回颗粒下层、CA3区和前额皮质星形胶质细胞的应激性损伤,这可能是其抗抑郁作用的重要细胞分子机制之一。
英文摘要：
OBJECTIVE To investigate the effect of the total flavonoids extracted from Xiao buxin-Tang（XBXT-2） on neuroglial cells in hippocampus and prefrontal cortex of chronically stressed rats.METHODS Rats were exposed to one or two unexpected stresses daily for 28 consecutive days.XBXT-2 25 and 50 mg·kg-1 were administered intragastrically once a day for 28 d.Astrocytes in hippocampal subgranular zone（SGZ）,CA3 and prefrontal cortex was detected by immunohistochemistry assay.RESULTS Immunohistochemistry results showed that 28 d stress produced significant reduction and dendritic shrinkage of astrocytes in hippocampal SGZ,CA3 and prefrontal cortex,and the absorbance was significantly decreased（P〈0.01）.Concomitant administration of XBXT-2 25 and 50 mg·kg-1 reversed these changes and significantly increased the absorbance（P〈0.01）.Positive drug imipramine exerted similar effects.CONCLUSION XBXT-2 can significantly reverse stress-induced injury in astrocytes,which may be a crucial molecular and cellular mechanism underlying its antidepressant action.
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