中文摘要：

Notch信号转导通路与细胞增生、分化、凋亡密切相关，与肿瘤的关系日益受到关注，以Notch通路为靶点的肿瘤治疗策略显示了其广阔的应用前景。本文将从肿瘤中Notch通路的调控、分子靶向治疗机制及应用进展方面做一综述。

英文摘要：

The Notch signaling pathway represents control cell proliferation, differentiation and apoptosis during development. Aberrant activation of this pathway contributes to tumorigenesis and genes in the Notch signaling pathway could be potential therapeutic targets. This review involves regulation of Notch pathway and molecular targeted therapy.