中文摘要：

我们以前证明那 B 房间受体联系了蛋白质 31 (BAP31 ) 是显著地在 colorectal 癌症的 upregulated 与正常 mucosa epithelia 相比。然而，它在 colorectal 癌症的表示模式和病理学的角色清楚地没被理解。在这研究，我们调查了 BAP31 的表示是否与 colorectal 癌症的 clinicopathological 参数被联系。BAP31 的表示模式被 immunohistochemistry 在两个主要肿瘤在织物 microarray 上检测并且从 120 个连续 colorectal 癌症病人配对远正常 mucosa 样品。而且， BAP31 蛋白质表示也在二十个 colorectal 腺瘤和八件肝转移样品被决定。在远正常 mucosa (P=0.000 ) 有在 64.17% 主要肿瘤和 6.67% 的 BAP31 的积极表示。BAP31 的否定表示与远转移(P=0.036 ) 和更低的肿瘤区别等级(P=0.001 ) 被相关。有 BAP31 否定的表示的病人与 BAP31 积极的表示与病人相比显示出显著地更低的全面幸存率(P=0.003 ) 。我们的结果证明 BAP31 可以在 colorectal 癌症作为一个候选人服务预示的标记，否定 BAP31 表示可以导致 colorectal 癌症的更好攻击的侵略。

英文摘要：

We previously showed that B cell receptor associated protein 31（BAP31） was significantly upregulated in colorectal cancer com- pared with normal mucosa epithelia. However, its expression pattern and pathological role in colorectal cancer are not clearly understood. In this study, we investigated whether the expression of BAP31 was associated with the clinicopathological parame- ters of colorectal cancer. The expression pattern of BAP31 was detected by immunohistochemistry on a tissue microarray in both primary tumor and paired distant normal mueosa samples from 120 consecutive colorectal cancer patients. Furthermore, BAP31 protein expression was also determined in twenty colorectal adenomas and eight liver metastasis samples. There was positive expression of BAP31 in 64.17% of primary tumors and 6.67% in distant normal mucosa （P=0.000）. Negative expression of BAP31 was correlated with distant metastasis （P=0.036） and lower tumor differentiation grade （P=0.001）. Patients with BAP31-negative expression showed significantly lower overall survival rate （P=0.003） compared to patients with BAP31-positive expression. Our results demonstrate that BAP31 may serve as a candidate prognostic marker in colorectal cancer and negative BAP31 expression may lead to more aggressive invasion of colorectal cancer.