欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
利用放射性同位素示踪技术研究超细颗粒物四氧化三铁模拟不溶性大气超细颗粒物对高血压模型大鼠的作用,测定不同时间点血液及其他器官的放射性分布,研究超细颗粒物在肺部的清除规律和进入体内的代谢途径。实验发现,无论是高血压动物还是正常动物,超细颗粒物能通过肺部进入血液,然后进入肝脏参与体内代谢,最后由肠道排出体外。高血压实验组超细颗粒物通过肺部进入血液明显快于对照组,但高血压组对超细颗粒物的排泄明显要慢于对照组。上述结果表明,由于不溶性超细颗粒物更易通过肺部进入体内又比较难于排除出体外的原因,超细颗粒物对患有心血管疾病（如高血压）的病人比正常人群有着更大的危害,患有心血管疾病的人群可能是大气颗粒物污染的易感人群。
英文摘要：
In order to investigate the adverse impact of hypertension SHR rats caused by simulated particle matter （nano ferric oxide） with radioactivity isotope tracer techniques was researched. By measured the radioactivity intensity in different tissues in different time point, we got the regular pattern of scavenging particles from pulmonary and the metabolism of the particles in a rat. The ultrafine particles can transport from the pulmonary to blood, then participated metabolism and expelled out of the body by feces in both hypertension rats and normal rats. The speed of unltrafine particulars transporting to blood is faster than the normal ones and expelled through feces in hypertension animals are less than those in normal rats. In conclusion, the ultrafine particles are more harmful to hypertension patients because the particles can easily transport from lung to blood and be hardly scavenged from body through feces, so the hypertension patients may be the sensitive group by ultrafine particle in the atmosphere.
同期刊论文项目
同项目期刊论文
Source identification of PM10 collected at a heavy-traffic roadside, by analyzing individual particl
PIXE characterization of PM10 and PM2.5 particulate matter collected during the winter season in Sha
Determination of extractable organohalogens in the atmosphere by instrumental neutron activation ana
A lead isotope record of Shanghai atmospheric lead emissions in total suspended particles during the
Characteristics of lead isotope ratios and elemental concentrations in PM10 fraction of airborne par
Quantification of extrapulmonary translocation of intratracheal-instilled particles in vivo in rats:
Regional distribution of organochlorinated pesticide in pine needles and its indication for socioeco
Instrumental neutron activation analysis of extractable organohalogens in PM2.5 and PM10 in Beijing,
Study of organohalogens in foodstuffs and envieonmental samples by neutron activation analysis and r
Pulmonary responses to fine particles: differences between the spontaneously hypertensive rats and W
Radiolabeling and in vitro evaluation of the polystyrene particles as a promising probe in biomedica
期刊信息
位置：