中文摘要：

目的探究紫檀茋（Pterostilbene,PTE）诱导白念珠菌凋亡的活性。方法通过分析白念珠菌凋亡细胞、坏死细胞和活细胞比例,检测Caspase酶活性、细胞内活性氧和线粒体膜电位,评价PTE诱导白念珠菌凋亡的活性。结果≥4μg/mL PTE处理后白念珠菌凋亡比例明显增加,Caspase酶活性显著升高,细胞内活性氧水平显著升高,线粒体膜电位显著降低。结论 PTE具有诱导白念珠菌凋亡的活性,该作用可能与活性氧积累和线粒体损伤相关。

英文摘要：

Objective To explore the activity of Pterostilbene（PTE）in inducing apoptosis of Candida albicans.Methods We used apoptosis,necrosis and overall viability assays,caspase activity determination,ROS measurement and mitochondrial membrane potential assay to evaluate the activity of PTE in inducing apoptosis of C.albicans.Results After C.albicans treated with ≥4μg/ml PTE,the percentage of apoptosis cells and activity of Caspase notably increased.Moreover,the mitochondrial membrane potential decreased significantly and the intracellular ROS increased.Conclusions PTE has an apoptosis-inducing effect on C.albicans,and this effect may be associated with ROS accumulation and mitochondrial injure.