白念珠菌是临床最常见的一种能产生生物被膜的致病真菌,所产生的生物被膜是导致高度耐药性和临床白念珠菌反复感染的直接原因。近年来,科学家们开始关注天然产物的抗生物被膜活性,以及不同药物联合应用的抗生物被膜效果,该文对抗白念珠菌生物被膜药物的研究进展作一综述。
Candida albicans is the most common fungal pathogen which can form biofilm, and the formation of biofilm leads to drug resistance and repeated infections in clinic. Over recent years we have witnessed the discovery of natural products with anti-biofilm activity and the development of combination-therapy against Candida biofilm. The antifungal agents with anti-biofilm activity were discussed in this review.