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中文摘要：
磁小体是一类存在于趋磁细菌体内,表面由脂质双分子层包裹,对磁场具有敏感性的纳米级单磁畴晶体.凭借其良好的生物相容性及表面可修饰等显著优势,可作为一种新型的天然磁性纳米载体应用于多种生物活性物质的固定负载,在靶向治疗方面有着广阔的应用前景.本文主要介绍了天然磁小体的来源及较人造磁性纳米颗粒的结构优势,概括了磁小体用作药物靶向载体的最新研究进展,并在此基础上探讨了磁小体载药研究中存在的问题及其发展前景.
英文摘要：
Bacterial magnetosomes （BMs） are lipid bi-membrane-bound nanometer-sized single-domain magnetic crystals synthesized by magnetotactic bacteria. BMs have been commonly used as a novel natural magnetic nanocarrier for various bioactive substances due to its significant advantages of good biocompatibility and surface modification, which shows a broad application prospect in targeting therapy. This article mainly introduces sources and advantages of BMs through comparing with artificial magnetic nanoparticles and then reviews the recent research concerned with application of BMs used as targeting drug-carriers. Unresolved problems and prospects on the drug loading research of BMs are also covered.
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Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a proce
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