中文摘要：

c6 月 dimerization 蛋白质 JDP2 是在基因抄写用作一个抑压者的 AP-1 家庭的一个成员。在 neuroblastoma 房间学习 JDP2 的角色，我们建立了一稳定地带 jdp2 的 transfected SH-SY5Y 房间线基因。我们的结果证明 JDP2 能支持 SH-SY5Y 房间的 neuronal 区别。展出的 SY5Y-JDP2 房间比它被 p21 的更高的表情和 cyclin D1 的强烈减小伴随的父母房间在 S 阶段和延迟的生长率降低房间的百分比。在结论， neuroblastoma 细胞生长上的 JDP2 的禁止的角色能为从细胞周期要撤退并且继续的细胞是关键的区别。

英文摘要：

c-Jun dimerization protein JDP2 is a member of the AP-1 family that serves as a repressor in gene transcription. To study the role of JDP2 in neuroblastoma cells, we have established a stably transfected SH-SY5Y cell line that carries jdp2 gene. Our results showed that JDP2 could promote neuronal differentiation of SH-SY5Y cells. The SY5Y-JDP2 cells exhibited lower percentage of cells in S phase and retarded growth rate than its parental cells that were accompanied by a higher expression of p21 and an intense reduction of the cyclin D1. In conclusion, the inhibitory role of JDP2 on neuroblastoma cell growth could be critical for the cells to be withdrawn from cell cycle and to proceed differentiation.