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中文摘要：
与染色质免疫降水(薄片) 和 DNA 微数组分析的倡导者(ChIP-on-chip ) ，我们分析了乙酰化作用的变化在上嘘在 all-trans retinoic 酸(RA ) 的一 H3 导致了 neuronal 房间区别。Neuroblastoma SH-SY5Y 房间为 24 h 和乙酰化作用与 RA 被对待在上嘘在基因的倡导者区域的一 H3 被检测。结果显示出那，在处理以后，乙酰化作用在上的水平嘘在染色体在 597 基因提高，并且控制与那些相比在另外的 647 基因减少了的一 H3。在摘要，我们成功地采用了一种高产量技术检测并且分析乙酰化作用的变化嘘在在 RA 的早噬菌体的人的染色体的一 H3 导致了 SH-SY5Y 房间的 neuronal 区别。
英文摘要：
With chromatin immunoprecipitation （CHIP） and promoter DNA microarray analyses （ChiP-on-chip）, we analyzed the variations of acetylation on histone H3 in all-trans retinoic acid （RA） induced neuronal cell differentiation. Neuroblastoma SH-SY5Y cells were treated with RA for 24 h and the acetylation on histone H3 in the promoter region of the genes was detected. Results showed that, after treatment, the level of acetylation on histone H3 elevated in 597 genes in the genome, and reduced in the other 647 genes compared with those of the control. In summary, we have successfully adopted a high throughput technique to detect and analyze variations of acetylation of histone H3 in human genome at the early phage of RA induced neuronal differentiation of the SH-SY5Y cells.
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