中文摘要：

目的：探讨C-反应蛋白（C-reactionpro-tein，CRP）基因rs6677719位点多态性与代谢综合症（metabolismsyndrome，MS）的关系。方法：研究对象来自从某乡镇6个村整群抽样调查人群，纳入301例MS对象作为病例组，同时选取年龄和性别与病例匹配的547例健康个体作为对照组，所有的研究对象完成了问卷调查、体格检查及临床生化指标检测。采用聚合酶链反应一限制性片段多态性（PCR-RFLP）方法完成CRP基因rs6677719位点基因分型，比较不同基因型在病例组和对照组中的分布差异，及其与血糖、血压和血脂等指标的关系。结果：关联分析结果表明，rs6677719位点变异与MS存在显著关联，相加模型和显性模型均有统计学意义，oR值（95％可信区间）分别为0．785（0．640-0．862）和0．659（0．489-0．889）。对照组TC基因型TG水平显著低于TT基因型（P〈0．05），而高密度脂蛋白（HDL-C）和低密度脂蛋白（LDI。-C）水平在TT、TC和CC基因型间存在显著线性关系（P〈0．05）。结论：CRP基因rs6677719位点变异与MS存在显著关联，并影响人体TG、HDL-C和LDLC代谢。

英文摘要：

To investigate the association of rs6677719 polymorphism in the Creactive protein gene with metabolic syndrome. METHODS： Stratified cluster sampling methodwas conducted to select 301 cases of metabolic syndrome and 547 healthy individuals who were matched with cases for age and gender from a community based population. Questionnaire was managed, and physical examination and blood biomarkers tests were conducted, and rs6677719 locus was detected by the method of polymerase chain reactionrestriction fragment length polymorphism （RFLP）. The distributions of TT, TC and CC genotype frequencies between cases and controls were compared and the association of rs6677719 polymorphism with serum glucose, blood pressure and blood lipids were analyzed. RESULTS：The results of association analysis indicated that rs6677719 variation had significant correlation with MS, and additive and dominant models presented statistical significances, oddsratios （OR） and corresponding 95% confidence interval （CI） were 0. 785 （0. 640-0. 862） and 0. 659 （0. 489-0. 889） ,respectively. The TG level of TC genotype carrier was significantly lower than that of TT genotype carrier in control group. Furthermore, the HDLC and LDLC levels of individuals presented significant linear trend in TT, TC and CC genotypes. CONCLUSION： The results in the present study suggest that rs6677719 polymorphism in CRP gene is as sociated with MS and the genetic variation sig- nificantly affects the TG, HDLC and LDLC of metabolisms in general population.