中文摘要：

目的：系统评价瘦素（LEP）及其受体（LEPR）基因多态性与高血压的相关性。方法：通过中国知网（CNKI）、维普、万方数据库、Pubmed、EMBASE等中外数据库,查全瘦素及其受体基因与高血压相关文献,按照Newcastle-Ottawa Scale质量评价标准对文献进行质量评价,使用STATA11.0对数据进行分析。结果：纳入21篇文献,共7 832例研究对象,病例组4 736例,对照组3 096例。Meta分析结果,LEP基因II/I在隐性和加性模型下与高血压相关（隐性模型：OR=2.16,95%CI=1.08-4.31,P=0.029,加性模型：OR=2.27,95%CI=1.08-4.79,P=0.031）;LEPR基因Gln223Arg在显性和等位基因模型下与高血压相关（显性模型：OR=1.55,95%CI=1.14-2.11,P=0.005,等位基因：OR=1.36,95%CI=1.09-1.71,P=0.007）;Lys109Arg与高血压无显著相关（显性模型OR=0.87,95%CI=0.67-1.14,P=0.307,隐性模型：OR=0.91,95%CI=0.70-1.20,P=0.099,加性模型：OR=0.92,95%CI=0.70-1.21,P=0.071,等位基因模型：OR=1.04,95%CI=0.80-1.35,P=0.830）。结论：LEP基因II/I与高血压相关,提示携带I/I基因型是高血压发病危险因素。LEPR基因Gln223Arg与高血压相关,且携带AA＋AG基因型、A等位基因是高血压发病的危险因素;Lys109Arg与高血压无显著相关。

英文摘要：

AIM：To evaluate the association between leptin gene and leptin receptor gene polymorphisms with hypertension.METHODS：CNKI,Wanfang database,Chongqing VIP network,Pubmed database and EMBASE database were researched.The data on the relationship between leptin/its receptor gene and hypertension were extracted and evaluated by software STATA11.0.RESULTS：Twenty-one studies involving 4 736 patients and 3 096 healthy people were included.The meta-analysis showed the II/I polymorphism of LEP gene was associated with hypertension in recessive genetic model and additive genetic model（recessive genetic model：OR=2.16,95% CI=1.08-4.31,P=0.029,additive genetic model：OR=2.27,95% CI=1.08-4.79,P=0.031）;the Gln223Arg polymorphism of LEPR gene was associated with hypertension in dominant model and allelic model（dominant model：OR=1.55,95% CI=1.14-2.11,P=0.005;allelic model：OR=1.36,95% CI=1.09-1.71,P=0.007）.No statistically significant correlation was found between the Lys109Arg polymorphism of LEPR gene and hypertension（dominant model：OR=0.87,95% CI=0.67-1.14,P=0.307,recessive genetic model：OR=0.91,95%CI=0.70-1.20,P=0.099,additive genetic model：OR=0.92,95% CI=0.70-1.21,P=0.071,allelic model：OR=1.04,95% CI=0.80-1.35,P=0.830）.CONCLUSION：There is no significant correlation between Lys109Arg polymorphism of LEPR gene and hypertension,but the II/I polymorphism of LEP gene and Gln223Arg polymorphism of LEPR gene are associated with hypertension.