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中文摘要：
目的从系统生物学层面探讨导致人体疼痛的分子机制。方法利用支持向量机（SVM）技术，构建疼痛相关蛋白相互作用（PPI）网络，结合GeneOntology注释信息和KEGG数据库的通路信息，推断导致人体疼痛的分子通路。结果疼痛信号网络主要涉及7条信号通路，包括MAPK信号通路、长时程抑制（LTD）、长时程增强（LTP）通路等；其中，ca2＋及Ras、PLCγ、PLCβ、PKA、IP3、CaM和PKC等蛋白分别在多个疼痛通路级联中发挥关键作用。结论中枢致敏现象在长时程抑制慢性疼痛的发病机制中起关键作用。
英文摘要：
Objective To study the mechanisms of pain based on systemic biology. Methods By applying the support vector machine （SVM） algorithm, protein-protein interactions （PPI） networks of pain were established in combination of the information available on Gene Ontology and KEGG databases for further deduction of the molecular pathways of pain in humans. Results Seven signaling pathways, including MAPK, LTD and LTP signaling pathways, were found to be involved in the signal networks of pain. Calcium, Ras,PLCγ、PLCβ、PKA、IP3、CaMand PKC played pivotal roles in multiple signal transduction pathway cascades. Conclusion Central sensitization plays a critical role in the development of chronic pain due to long-term depression.
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