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中文摘要：
固有免疫参与形成抗肿瘤的第一道防线,并在肿瘤免疫过程中发挥重要作用。但是,固有免疫非但不能清除肿瘤细胞,反而会引起抑癌作用下降,甚至转变成促进肿瘤生长的帮凶,具体机制尚无定论。近年来研究发现,唾液酸结合的免疫球蛋白样凝集素（sialic acid-binding immunoglobulin-like lectin,Siglec）-7/9参与调节肿瘤固有免疫,可能是未来肿瘤患者免疫治疗的新靶点。本文将就肿瘤免疫编辑学说、固有免疫细胞与肿瘤免疫的联系以及Siglec-7/9在肿瘤免疫中的作用作一综述。
英文摘要：
Innate immunity constitutes the first line of defense against tumor, which plays an important role in tumor immunity. However, it does not destroy tumor cells but decreases the inhibitory effect and even promotes tumor growth, irrespective of the uncertain mechanism. Recent studies have shown that sialic acid-binding immunoglobulin-like lectin（Siglec）-7/9 is involved in the regulation of tumor innate immunity, which may become a new target for future immunotherapy of patients with tumor. Collectively, the progresses on cancer immunoediting theory, the links between innate immune cells and tumor immunity, and the role of Siglec-7/9 in tumor immunity were reviewed in this article.
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