中文摘要：

甲状腺激素受体相关蛋白15（TRIP15）是一个核受体家族的选择性转录共抑制子,参与构成COP9信号复合体,调节机体蛋白质的降解。TRIP15与涉及转录调节、细胞周期调控、DNA损伤修复的多种生物大分子相互作用,参与细胞增殖、分化、凋亡等重要生理过程,其表达调控的信号通路与肿瘤、脂质代谢紊乱及内分泌疾病的发生与发展密切相关。TRIP15具有复杂的蛋白质相互作用网络及多样的生物学功能,可能会成为疾病治疗的新靶点。

英文摘要：

Thyroid hormone receptor interacting protein 15（TRIP15） is a transcriptional co-repressor for selected nuclear receptor family and constitutes COP9 signalosome complex which involves in protein degradation. It also interacts with a number of molecules involved in transcription control,cell cycle modulation and DNA repair. These functional studies have revealed that TRIP15 engages in the vital cellular process such as proliferation,differentiation and apoptosis,thus associates with neoplasms,lipid metabolism disorders,endocrine disorders and so on. Though the function of TRIP15 is largely unknown,its complicated protein interacting network and multifunctional potentials may present a new target for medical intervention.