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中文摘要：
哺乳动物细胞受到DNA损伤刺激时,生长阻滞和DNA损伤诱导蛋白45α （GADD45α）可与多种生物大分子相互作用在细胞周期阻滞、DNA损伤修复、细胞增殖、凋亡等细胞应答反应中发挥重要的调控作用.GADD45α表达调控的信号通路与肿瘤、心血管疾病等多种疾病的发生、发展密切相关.阐明GADD45α的功能及其在疾病中的作用机制,有助于了解许多疾病的发病机制,为诊断及治疗提供新的靶点.
英文摘要：
In responses to DNA damage,GADD45α interacts with a number of molecules and plays an important role in the regulation of DNA repair,cell cycle,cell proliferation,and apoptosis,the effects of which are closed related to the development of cancer,cardiovascular diseases and other diseases.Elucidation on these functions and mechanisms of GADD45α will be helpful for understanding the pathogenesis and establishing novel diagnostic and therapeutic targets.
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