中文摘要：

目的：探讨幽门螺旋杆菌感染等因素与大肠癌发生的关系。方法：用配对病例对照方法研究大肠癌的危险因素,按性别、年龄、城乡分布进行1：1配对。资料分析使用单因素及多因素Logistic回归。结果：多因素分析显示,Hp感染与大肠癌无相关性。有肿瘤家族史、细粮摄入量高以及常吃红烧鱼增加了患大肠癌的危险,其OR值分别为3.259、3.067、1.838;而体力劳动、有非类固醇类抗炎药用药史、淡水鱼摄入量高可能是大肠癌发病的保护性因素,其OR值分别为0.164、0.232、0.543。结论：Hp感染与大肠癌的形成无相关性。有肿瘤家族史、细粮摄入量高以及常吃红烧鱼可能是大肠癌的危险因素,而从事适当的体力劳动、有非类固醇类抗炎药用药史、摄入淡水鱼较多可能是大肠癌的保护因素。

英文摘要：

Objective： To study the relationship between helicobacter pylori infection, other factors and colorectal cancer. Methods： A 1 ： 1 matched case control study was used to study the relationship between helicobacter pylori infection, other factors and colorectal cancer. Univariate and multivariate conditional Logistic regression analyse were used to analysis the relationship. Results： Univariate conditional Logistic regression analysis results showed that marine products,refined food, mental stress, Hp infection, History of using non - steroid anti - inflammatory and employment type were significant related with colorectal cancer, the OR were 1. 9 85 , 1.661 , 1. 5 99,0.62 3,0. 212 and 0. 170; Muhivariate conditional Logistic regression analysis results showed that Hp infection and colorectal cancer were no relation. Family history of other tumours, refined food, fish cooked with soybean sauce and river fish, history of using non - steroid anti - inflammatory agent, employment type were related with colorectal cancer, the OR were 3. 259,3. 067,1. 838,0.543,0.232 and 0. 164. Conclusion： Hp infection is not related with colorectal cancer. In addition, positive family history of other cancers, taking more refined foods and taking fish cooked with soybean sauce often may be the risk factors of colorectal cancer, and doing adequate manual work ,using non- steroid anti - inflammatory agent,taking more fresh water fish may be the protective factors of colorectal cancer.