中文摘要：

目的探讨准分子激光照射对寻常性银屑病患者外周血Th17／Treg失衡及相关细胞因子表达的影响。方法选择寻常性银屑病患者38例为准分子激光治疗组，每周治疗2次，共治疗8周；另选健康体检者38例为对照组。采用流式细胞术检测各组治疗前后外周血，Th17和Treg百分比，采用ELISA法检测各组治疗前后血清中TGF-β1和IL-6的含量。结果经准分子激光治疗后，银屑病患者外周血Th17百分比（1．28±0．26）％，Thl7／Treg比值（0．214-0．09）及IL-6水平（97．34±8．46）ng／L均比治疗前有明显降低，而Treg百分比（5．08±1．34）％和TGF—D1含量（525．17±24．56）ng／L比治疗前有显著升高，差异均有统计学意义（P均〈0．01）。结论准分子激光照射可调节寻常性银屑病患者外周血Th17／Treg细胞失衡比值及相关细胞因子的表达水平。

英文摘要：

Objective To study the effects of excimer laser irradiation on the imbalanced ratio between Th17/Treg and their cytokines expression in patients with psoriasis vulgaris. Methods Thirty-eight patients with psoriasis vulgaris were treated with excimer laser two times per week for 8 weeks. 38 healthy persons were selected as the control group. The peripheral blood levels of Th17 and Treg were measured by flow cytometry and the serum levels of TGF-β1 and IL-6 were measured by ELISA before and after treatment. Results After the laser treatment,the percentage of Thl7（ 1.28 ±0. 26） % ,the ratio between Thl7 and Treg（0. 21 ±0.09） ,and the level of IL-6 （97.34± 8.46） ng/L had all decreased significantly （ P 〈 0. 01 ）, however, the percentage of Treg cells （5.08 ± 1.34） % and TGF-β1 levels （ 525.17 ± 24. 56 ） ng/L had significantly increased （ P 〈 0. 01 ）. Conclusion The excimer laser irradiation treatment can regulate the imbalanced ratio between Th17/Treg and influence their cytokines expression in patients with psoriasis vulgaris.