中文摘要：

目的：观察三种抗病毒药物联合用于阻断妊娠合并艾滋病母婴传播的疗效和安全性。方法选择住院分娩的妊娠合并艾滋病患者26例，孕期均采用三种抗病毒药物治疗，监测用药期间孕妇的血常规、肝功能、CD ＋4细胞、及不良反应，共安全分娩26例新生儿，进行18个月的跟踪检测，并分析阻断效果。结果26例孕妇抗病毒治疗前 CD ＋4低于正常值共3例，分别为（182／μL，196／μL，189／μL），抗病毒治疗后 CD ＋4细胞为（489／μL，616／μL，589／μL），在正常范围，抗病毒前后 CD ＋4细胞数量分别为（413．5±0．39）／μL、（435．6±0．53）／μL，差异无统计学意义（P ＞0．05）。孕妇服用抗病毒药物期间不良反应轻，仅轻度贫血3例，无其他严重不良反应发生，26例新生儿随访到18个月 HIV 抗体检测均为阴性，无一例新生儿艾滋病感染。结论三种抗病毒药物联合阻断妊娠合并艾滋病疗效满意，建议及早抗病毒治疗，抗病毒药物对孕妇治疗安全有效，不良反应少。

英文摘要：

Objective To observe the efficacy and safety of three antiviral drug combinations for blocking the pregnancy merge HIV mother -to -child transmission.Methods 26 pregnancy patients with HIV /AIDS in hospital delivery were chosen,adopted three kinds of antiviral drug treatment during pregnancy.During the treatment,the preg-nant women blood routine,liver function,CD ＋4 cells,and adverse reactions were monitored.A total of 26 cases of new-born,safe childbirth for 18 months of tracking detection,and analyzed the blocking effect.Results Before antiviral therapy,of 26 pregnant women,CD ＋4 was lower than normal in 3 cases （182 /μL,196 /μL,189 /μL）,after antiviral treatment,the CD ＋4 cells levles were in the normal range （489 /μL,616 /μL,489 /μL）.Number of CD ＋4 cells before and after antiviral treatment were （413.5 ±0.39）/μL,（435.6 ±0.53）/μL respectively,there was no statistically significant difference （P 〉0.05）.Pregnant women who took antiviral drugs had light adverse reactions,only mild ane-mia （3 cases）,no other serious adverse reactions.26 cases of newborn were followed up to 18 months,they were nega-tive for HIV antibody detection,no case of neonatal infection.Conclusion The effect of three kinds of antiviral drugs joint on the block pregnancy with AIDS is very significant,recommended the early antiviral treatment,antiviral therapy is safe and effective for the pregnant women,with less adverse reaction.