中文摘要：

缺氧微环境是实体肿瘤的典型特征,被认为是导致肿瘤进展及预后差的独立因素;作为肿瘤干细胞（cells,CSCs）壁龛的关键组成部分,缺氧微环境对肿瘤干细胞在肿瘤中的演进以及抗凋亡能力起着重要的作用。缺氧诱导因子（hypoxia-inducible factors,HIFs）是肿瘤适应缺氧微环境的中心调节因子,能够诱导肿瘤干细胞生物学行为的改变如抗凋亡、增强耐药基因表达、促进肿瘤侵袭转移等,从而加速肿瘤恶性转变;同时HIFs也是维持肿瘤干细胞其干细胞特性的主要影响因素。本文对HIFs在维持肿瘤干细胞生物学特性的研究进展进行综述。

英文摘要：

Hypoxic microenvironment is a typical characteristic of solid tumors and is considered an independent risk factor in tumor progression and poor prognosis. Hypoxic microenvironment is a critical part of cancer stem cell （CSC） niche and plays an important role in the evolution of cancer stem ceils in tumors and in apoptosis resistance. As a key factor in the tumor＇s adaption to hypoxic rnicroenvironment, hypoxia inducible factors （HIFs） can induce biological behavioral changes in CSCs that can accelerate tumor malignant transformation. Such behavioral changes include anti-apoptosis, enhancement of drug-resistance gene expression, and tumor invasion and metastasis. HIFs are also among the main factors affecting the capacity of CSCs to maintain their biological characteristics. In this review, the authors focus on recent advances in our understanding of the role that HIFs play in maintaining the biological characteristics of CSCs.