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Magnetic nanoparticle-based cancer therapy

ISSN号：1674-1056
期刊名称：Chinese Physics B
时间：2013.2
页码：027506-027506
分类：Q523[生物学—生物化学] TQ174.759[化学工程—陶瓷工业;化学工程—硅酸盐工业]
作者机构：[1]Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China, [2]Department of Otorhinolaryngology Head & Neck Surgery. Clinical Division of Surgery, Chinese PLA (People's Liberation Army) General Hospital, Beijing 100853 China, [3]College of Chemistry and Molecular Engineering, Peking University, Beijing 100871. China
相关基金：Project supported by the National Natural Science Foundation of China （Grant Nos. 51125001,51172005,and 90922033）; the Research Fellowship for International Young Scientists of the National Natural Science Foundation of China （Grant No. 51250110078）; the Doctoral Program of the Education Ministry of China （Grant No. 20120001110078）; PKU COE-Health Science Center Seed Fund
相关项目：磁性功能材料

作者： Hou Yang-Long|Hou Yang-Long|Gao Song|Gao Song|

关键词：磁性纳米粒子, 癌症治疗, 基础, 磁共振成像, 生物医学, 表面改性, 死亡原因, 肿瘤治疗, magnetic nanoparticles,cancer therapy,hyperthermia,drug delivery,targeting,magnetic reso-nance imaging

中文摘要：

Nanoparticles(NPs) with easily modified surfaces have been playing an important role in biomedicine.As cancer is one of the major causes of death,tremendous efforts have been devoted to advance the methods of cancer diagnosis and therapy.Recently,magnetic nanoparticles(MNPs) that are responsive to a magnetic field have shown great promise in cancer therapy.Compared with traditional cancer therapy,magnetic field triggered therapeutic approaches can treat cancer in an unconventional but more effective and safer way.In this review,we will discuss the recent progress in cancer therapies based on MNPs,mainly including magnetic hyperthermia,magnetic specific targeting,magnetically controlled drug delivery,magnetofection,and magnetic switches for controlling cell fate.Some recently developed strategies such as magnetic resonance imaging(MRI) monitoring cancer therapy and magnetic tissue engineering are also addressed.

英文摘要：

Nanoparticles（NPs） with easily modified surfaces have been playing an important role in biomedicine.As cancer is one of the major causes of death,tremendous efforts have been devoted to advance the methods of cancer diagnosis and therapy.Recently,magnetic nanoparticles（MNPs） that are responsive to a magnetic field have shown great promise in cancer therapy.Compared with traditional cancer therapy,magnetic field triggered therapeutic approaches can treat cancer in an unconventional but more effective and safer way.In this review,we will discuss the recent progress in cancer therapies based on MNPs,mainly including magnetic hyperthermia,magnetic specific targeting,magnetically controlled drug delivery,magnetofection,and magnetic switches for controlling cell fate.Some recently developed strategies such as magnetic resonance imaging（MRI） monitoring cancer therapy and magnetic tissue engineering are also addressed.