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Dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle

期刊名称：Front Phys
时间：2014.9.12
页码：519-522
分类：Q945.11[生物学—植物学] TB383[一般工业技术—材料科学与工程]
作者机构：[1]Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region Ministry of Education, College of Animal Science, Guizhou University, Guiyang 550025, China, [2]Soft Condensed Matter Laboratory, College of Science, Guizhou University, Guiyang 550025, China, [3]State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China, [4]Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou 213164, China, [5]Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China
相关基金：Acknowledgements are made to the National Natural Science Foundation of China （Grant Nos. 11047022, 11204045, and 31360215）, the Research Foundation from Min- istry of Education of China （Grant No. 2012152）, Guizhou Provincial Tracking Key Program of Social Development （Grant Nos. SY20123089 and SZ20113069）, the Natural Science Foundation of Guizhou Province （Grant No. J20122166） and the Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education （Chongqing University）.
相关项目：DNA凝聚过程中离子浓度效应及温度效应研究

作者：刘艳辉|

关键词：尺寸依赖性, 病毒样颗粒, 复合物, 配体, 受体, 半径, 内吞, 纳米颗粒, cellular uptake, depletion effects, dimension of receptor-ligand complex, elasticitytheory

中文摘要：

最近的实验指出了那细胞的举起强烈依赖于 endocytosed nanoparticles 和由 transferrin 涂的像病毒的粒子在 50 nm 附近的 endocytosed 的最佳的半径的物理尺寸。作为一样的时间， receptor-ligand 建筑群的尺寸在房间环境在蛋白质的尺寸依赖者排除上有强壮的效果。由这些试验性的结果启发了，一个连续统橡皮模型被构造解决在 receptor-ligand 建筑群和 endocytosed 的最佳的半径的尺寸之间的关系像病毒的粒子。这些结果证明像病毒的粒子取决于的 endocytosed 的最佳的半径复杂的 receptor-ligand 的尺寸和 receptor-ligand 建筑群还原剂的尺寸弄空地区。

英文摘要：

Recent experiments have pointed out that cellular uptake is strongly dependent on the physical dimensions of endocytosed nanoparticles and tile optimal radius of endocytosed virus-like particle coated by transferrin is around 50 nm. As the same time, the dimensions of receptor-ligand complex have strong effects on the size-dependent exclusion of proteins ill cell environments. Inspired by these experimental results, a continuum elastic model is constructed to resolve the relationship between the dinlensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle. These results demonstrate that the optimal radius of endocytosed virus-like particle depends on the dimensions of reeeptor-ligand complex and the dimension of receptor-ligand complex reduces the depletion zone.

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