中文摘要：

二恶英（TCDD）是一种持久性环境污染物质，它的高残留性、致畸性已经引起世界各国的重视。以青鳉胚胎作为试验动物模型，从分子水平探讨了TCDD对青鳉胚胎脊椎的毒性作用机制。结果表明：TCDD造成青鳉幼鱼脊椎生成障碍，脊椎生成数目与TCDD染毒浓度呈负相关。TCDD引起青鳉胚胎软骨发育的变化与Sox9b的表达降低密切相关。

英文摘要：

The dioxin （TCDD） is a persistent environmental pollutants, its high residue and teratogenicity has attracted great attention in the world. Using medaka embryos as experimental animal model,the mechanism of TCDD toxicity on medaka embryo spine was explored from molecular level. The results showed that：TCDD caused a medaka juvenile spine formation disorder,and the spine number was negatively correlated with TCDD concentrations. TCDD also caused changes in embryonic cartilage development in medaka, and closely related with the decreased expression of Sox9b.