中文摘要：

目的观察P2X1受体在正常大鼠和膀胱过度活动症（OAB）大鼠逼尿肌中的表达情况,探讨P2X1受体在OAB膀胱功能调节中的作用及其与膀胱功能障碍的关系。方法成功建立OAB大鼠模型后,将纳入实验的大鼠分为正常对照组、模型对照组和OAB组,采用RT-PCR、免疫组化等检测方法,观察P2X1受体在正常大鼠和OAB大鼠逼尿肌中的表达情况。结果正常对照组、模型对照组及OAB组的膀胱逼尿肌中均有P2X1受体的表达,P2X1受体在正常对照组及模型对照组大鼠膀胱逼尿肌中的表达较OAB组低,差异均具有显著性（P〈0.01）。结论OAB大鼠逼尿肌中P2X1受体表达较正常大鼠增高,提示P2X1受体可能对OAB膀胱舒缩功能障碍的发病机制起重要作用;这种增高可能与膀胱功能受损密切相关。

英文摘要：

Objective To observe the expression of P2X1 receptor in the detrusors of both normal rats and overactive bladder （OAB）rats. Evaluate the function and role of the P2X1 receptors in the OAB bladder, and discuss the relationship botween P2X1 receplor and bladder dysfunction. Methods Divided the experimental rats into normal control group, model control group and OAB group after establishing the rats model of overactive bladder successfully. By RT-PCR and Imrounohistochemistry detection methods, observe the expression of P2X1 receptor in the detrusors of both normalrats and OAB rats. Results The expression of P2X1 receptor was detected in the normal control group, model control group and also in OAB group.The expression of P2X1 receptor in the rats detrusor of normal control group is lower than that in the OAB group, with statistical significance （ P 〈 0.01 ）. Conclusion The expression of P2X1 receptor in the detrusor of OAB rats is higher than that of normal rats, which demonstrating that P2X1 receptor may play an important role in the mechanism of OAB bladder systolic and diastolicdysfunction.This is likely related to bladder dysfunction closely .