中文摘要：

目的 探讨类风湿关节炎（RA）患者血清Dickkopf-1的表达情况及临床意义.方法 回顾性分析139例RA患者的临床资料,包括病史、压痛关节数（TJC）、肿胀关节数（SJC）、血小板、红细胞沉降率（ESR）、C-反应蛋白（CRP）、类风湿因子（RF）、抗核抗体（ANA）、抗角蛋白抗体（AKA）、抗核周因子（APF）、抗环瓜氨酸肽抗体（抗CCP抗体）、Dickkopf-1及影像学（X线）分期.采用RA疾病活动量表（DAS）进行评估,并将ESR、CRP引入计算DAS44评分.分析Dickkopf-1与RA临床特点、DAS44评分等的关系.结果 RA患者血清Dickkopf-1表达水平为（2.70±0.46）μg/L.RA患者血清Dickkopf-1表达水平与性别、年龄、病程、CRP、血小板、ANA、AKA、APF、RF和影像学分期无关（P〉0.05）.血清Dickkopf-1水平与TJC、SJC、ESR、DAS44-ESR评分、DAS44-CRP评分和抗CCP抗体相关（r=0.200、0.291、0.178、0.222、0.199和0.278,P=0.019、0.001、0.037、0.009、0.028和0.012）.结论 RA患者血清Dickkopf-1表达水平与疾病活动相关,参与了RA疾病的发生和发展过程.

英文摘要：

Objective To investigate the serum expressions and clinical significance of Dickkopf-1 in patients with rheumatoid arthritis （RA）. Methods The clinical data of 139 patients with RA were retrospectively analyzed, including the disease history, tender joint count （TJC）, swollen joint count （SJC）, platelet, erythrocyte sedimentation rate （ESR）, C-reactive protein （CRP）, rheumatoid factor （RF）, anti-nuclear antibody （ANA）, antikeratin antibody （AKA）, anti-perinuclear factor （APF）, anti cyclic citrullinated peptide antibody （anti-CCP）, Dickkopf-1 and radiological （X-ray） staging. The disease activity scale （DAS） was evaluated, and the ESR and CRP levels were included. The relationship between Dickkopf-1 and the clinical data of RA, DAS44 score was analyzed. Results The serum level of Dickkopf-1 in patients with RA was （2.70 ± 0.46） μg/L. There was no relationship between serum Dickkopf-1 level and gender, age, course of disease, CRP, platelet, ANA, AKA, APF, RF, radiological staging in patients with RA （P〉0.05）. The serum Dickkopf-1 level was significantly associated with TJC, SJC, ESR, DAS44-ESR score, DAS44-CRP score and anti-CCP （r = 0.200, 0.291, 0.178, 0.222, 0.199 and 0.278, P = 0.019, 0.001, 0.037, 0.009, 0.028 and 0.012）. Conclusions The serum Dickkopf-1 expression level is closely related to the occurrence and development of RA. Dickkopf-1 may contribute to diagnose the disease activity in patients with RA.